Silent Synapses in Neural Plasticity: Current Evidence
نویسندگان
چکیده
منابع مشابه
Silent synapses in neural plasticity: current evidence.
Silent synapses, defined as structural specializations for neurotransmission that do not produce a physiological response in the receiving cell, may occur frequently in neural circuits. Their recruitment to physiological effectiveness may be an important component of circuit modification. In several nervous systems, evidence from electrophysiological and optophysiological measurements has estab...
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In this review I discuss the evidence that some glutamatergic synapses exist that lack surface-expressed postsynaptic AMPA receptors (AMPARs) but contain NMDA receptors opposed to a functional release site. I have summarised the electrophysiological, anatomical and cell biological evidence for such postsynaptically silent synapses, and data that support the idea of rapid AMPAR insertion at sile...
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*Department of Psychiatry The existence of silent or ineffective synapses in the †Department of Cellular and Molecular spinal cordwas proposed over 20 years ago (Wall, 1977), Pharmacology based on experimentally induced rapid changes in the Department of Physiology ability of afferents to evoke single unit activity. However, University of California a limitation of this approach was that it was...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 1999
ISSN: 1072-0502
DOI: 10.1101/lm.6.6.542